Comprehensive Bioinformatics Analysis Reveals Associations between the DNA Damage Response and Osteoarthritis
Elevated expression of DDR-related genes and enhanced activity of DDR signaling pathways were observed in conjunction with OA onset and progression. Our computational analysis prioritizes identified DDR-OA genes as high-confidence candidates for further experimental investigation.
Authors
- Junjie Gao (ORCID: https://orcid.org/0000-0003-4820-8524)
- Jan Vijg (ORCID: https://orcid.org/0000-0002-8457-9595)
- Chen Zheng (ORCID: https://orcid.org/0000-0002-9028-3811)
- Shixiang Sun (ORCID: https://orcid.org/0000-0001-5499-2963)
- Zhenzhen Lu (ORCID: https://orcid.org/0000-0002-4394-7232)
- Changqing Zhang (ORCID: https://orcid.org/0000-0002-7408-4126)
- Peijun Ren (ORCID: https://orcid.org/0000-0002-4544-2289)
Institutions
- Albert Einstein College of Medicine (US)
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Gerontology
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1159/000547422
- Citations
- 1
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.05