Comparison of Frequency-Specific Transcranial Alternating Current Stimulations on Cognitive Function in Patients With Mild Cognitive Impairment

These findings suggest that gamma tACS enhances working memory, processing speed, and cognitive flexibility, potentially due to its modulating neural activity within the DLPFC and restoring effective theta-gamma coupling. Conversely, theta tACS did not yield improvements, likely because of the elevated baseline theta levels and disrupted oscillatory dynamics observed in patients with MCI. This study underscores the potential of gamma tACS as a promising intervention for cognitive decline in MCI and further suggests the necessity of a comprehensive approach that considers the electrophysiological abnormalities and dynamic oscillatory patterns in MCI.