Immunosuppressive therapy management during sepsis in kidney transplant recipients: a prospective multicenter study
This study is the first prospective investigation to suggest an association between MPA discontinuation and adverse outcomes during sepsis in critically-ill KTRs. These findings must be interpreted with caution given the potential confounding introduced by SARS-Cov-2-specific treatment protocols. Further interventional trials are necessary to optimize immunosuppressive drug strategies in KTRs during sepsis.
Authors
- Côme Bureau (ORCID: https://orcid.org/0000-0003-1597-8127)
- Lara Zafrani
- Raphaël Clère-Jehl (ORCID: https://orcid.org/0000-0002-8550-4245)
- Laure Calvet
- Romain Arrestier (ORCID: https://orcid.org/0000-0002-6779-5368)
- Benjamin Zuber (ORCID: https://orcid.org/0000-0003-4030-5311)
- Adrien Joseph (ORCID: https://orcid.org/0000-0002-5278-8966)
- Paul Gabarre
- Anne‐Sophie Moreau (ORCID: https://orcid.org/0000-0003-2933-5069)
- Laurent Argaud
- Jean-Herlé Raphalen
- Stéphanie Pons
- Valentin Rivet
Institutions
- Délégation Paris 5 (FR)
- Brigham and Women's Hospital (US)
- Hôpital Necker-Enfants Malades (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Hôpital Roger Salengro (FR)
- Hôpital Saint-Antoine (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Hôpital Ambroise-Paré (FR)
- Hôpital Saint-Louis (FR)
- Hôpital Foch (FR)
- Hôpital Civil, Strasbourg (FR)
- Groupe de recherche clinique en anesthésie réanimation médecine périopératoire (FR)
Publication Details
- Journal
- Annals of Intensive Care
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1186/s13613-025-01523-2
- Citations
- 3
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.96