Acute Localized Exanthematous Pustulosis After Face and Neck Rhytidectomy: A Case of Locus Minoris Resistentiae

We report a case of a 52-year-old woman who developed acute localized exanthematous pustulosis, a rare drug reaction, after cefazolin administration for a face and neck surgery. The rash was confined to the surgical areas, suggesting a locus minoris resistentiae, a phenomenon where a site of previous injury becomes more vulnerable to a subsequent insult. The rash resolved with corticosteroids. We review the clinical features, causes, and management of acute localized exanthematous pustulosis.