Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy and Increases the Risk of Colitis
Our study is the first to explore the impact of GI infection before ICI therapy on IMC risk and survival. We found that prior GI infection was associated with an increased incidence of IMC and an increased risk of mortality in patients receiving ICIs.
Authors
- Tanvi Gupta (ORCID: https://orcid.org/0000-0002-5443-5056)
- Mehnaz A. Shafi (ORCID: https://orcid.org/0000-0003-2614-7580)
- Hamza Adel Salim (ORCID: https://orcid.org/0000-0002-5208-8425)
- Carolina Colli Cruz (ORCID: https://orcid.org/0000-0001-7065-3769)
- Ayesha Khan (ORCID: https://orcid.org/0000-0002-0470-9047)
- Kian Abdul-Baki
- Yan Zhou (ORCID: https://orcid.org/0000-0001-6685-2634)
- Linfeng Lu (ORCID: https://orcid.org/0000-0002-5703-5007)
- Malek Shatila (ORCID: https://orcid.org/0000-0001-8503-7811)
- Krishnavathana Varatharajalu
- Anthony J. Olszanski (ORCID: https://orcid.org/0000-0001-5276-5898)
- Varun Vemulapalli
- Pablo C. Okhuysen (ORCID: https://orcid.org/0000-0002-1596-3411)
- Garrett J. Coleman (ORCID: https://orcid.org/0009-0003-4489-9206)
- Elliot Baerman (ORCID: https://orcid.org/0000-0002-3750-7855)
- Cristina Natha
- Yinghong Wang (ORCID: https://orcid.org/0000-0002-5148-6130)
- Hao Chi Zhang (ORCID: https://orcid.org/0000-0003-0330-0167)
- Irene Lee (ORCID: https://orcid.org/0000-0003-0552-7429)
- Christopher Fan (ORCID: https://orcid.org/0000-0002-7117-6885)
- Raakhi Menon
- Andrew Sullivan
- Andres Urias Rivera
- Kei Takigawa
Institutions
- Fox Chase Cancer Center (US)
- Memorial Hermann (US)
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- Methodist Hospital (US)
- The University of Texas Health Science Center (US)
- The University of Texas Medical Branch at Galveston (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cam4.71123
- Citations
- 1
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- University of Texas MD Anderson Cancer Center