Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy and Increases the Risk of Colitis

Our study is the first to explore the impact of GI infection before ICI therapy on IMC risk and survival. We found that prior GI infection was associated with an increased incidence of IMC and an increased risk of mortality in patients receiving ICIs.

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Publication Details

Journal
Cancer Medicine
Published
2025-08-01
DOI
https://doi.org/10.1002/cam4.71123
Citations
1
Primary Topic
Clostridium difficile and Clostridium perfringens research
Type
article
Field-Weighted Citation Impact
1.40

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article

Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy and Increases the Risk of Colitis

Tanvi Gupta, Mehnaz A. Shafi, Hamza Adel Salim, Carolina Colli Cruz et al.
1 citations
Cancer Medicine
Clostridium difficile and Clostridium perfringens research
1.40
article

Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy and Increases the Risk of Colitis

Tanvi Gupta, Mehnaz A. Shafi, Hamza Adel Salim, Carolina Colli Cruz, Ayesha Khan, Kian Abdul-Baki, Yan Zhou, Linfeng Lu, Malek Shatila, Krishnavathana Varatharajalu, Anthony J. Olszanski, Varun Vemulapalli, Pablo C. Okhuysen, Garrett J. Coleman, Elliot Baerman, Cristina Natha, Yinghong Wang, Hao Chi Zhang, Irene Lee, Christopher Fan, Raakhi Menon, Andrew Sullivan, Andres Urias Rivera, Kei Takigawa
article en
1 citations

Abstract

Our study is the first to explore the impact of GI infection before ICI therapy on IMC risk and survival. We found that prior GI infection was associated with an increased incidence of IMC and an increased risk of mortality in patients receiving ICIs.

Cancer MedicineVol. 14(15)
Fox Chase Cancer Center (US), Memorial Hermann (US), The University of Texas MD Anderson Cancer Center (US), Baylor College of Medicine (US), Methodist Hospital (US), The University of Texas Health Science Center (US), The University of Texas Medical Branch at Galveston (US), The University of Texas Health Science Center at Houston (US)
University of Texas MD Anderson Cancer Center
Good health and well-being
Openalex Percentile: Top 17%
Clostridium difficile and Clostridium perfringens research
1.40
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