Histone lactylation-boosted AURKB facilitates colorectal cancer progression by inhibiting HNRNPM-mediated PSAT1 mRNA degradation
Our findings uncover a previously unappreciated, kinase-independent function of AURKB in CRC, redefining its therapeutic relevance beyond kinase inhibition. This highlights the need for broader targeting strategies, including PROTAC-mediated degradation of AURKB and pharmacological inhibition of the AURKB/PSAT1 axis, to fully harness its role in CRC treatment.
Authors
- Xintian Zhang (ORCID: https://orcid.org/0000-0002-5991-7919)
- Liang Yu (ORCID: https://orcid.org/0000-0002-5456-1941)
- Yichao Hou (ORCID: https://orcid.org/0000-0003-1506-7382)
- W.T. Chen (ORCID: https://orcid.org/0000-0001-8325-5663)
- Qinfen Xie
- Jinjin Peng
- Yuyi Li (ORCID: https://orcid.org/0000-0002-2433-4799)
- Di Wu (ORCID: https://orcid.org/0000-0002-2739-1625)
- Han Yao (ORCID: https://orcid.org/0000-0002-3409-8136)
- Jing Feng (ORCID: https://orcid.org/0000-0003-0242-3114)
- Xu Che (ORCID: https://orcid.org/0000-0003-4193-3264)
- Linjing Li (ORCID: https://orcid.org/0000-0001-5175-8215)
- Xiangjun Meng (ORCID: https://orcid.org/0000-0001-9657-0021)
- Jiaqing Chen
Institutions
- Yahoo (United Kingdom) (GB)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Veterinary Research Institute (CN)
- Shanghai Clinical Research Center (CN)
- Shanghai Micro Electronics Equipment (China) (CN)
- Xuchang University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s13046-025-03498-1
- Citations
- 4
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University