Precision‐Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart‐Warning of Weightlessness Induced Bone Loss
Surface-Enhanced Raman Scattering (SERS) shows promise for monitoring health during space missions, particularly in assessing the effects of microgravity and radiation. However, traditional SERS sensors struggle with precise interfacial engineering, leading to a relatively poor assembly efficiency, and are unable to meet the practical needs of extreme spaceflight environments. To address this, it is designed and fabricated precision-arranged DNA origami plasmonic nanoantennas. By leveraging DNA origami's addressability, it is built a 3 × 4 antenna array with a controlled spacing of 21.76 nm, enhancing assembly efficiency fourfold compared to disordered systems. The ordered system enabled accurate detection of calcium ions, interleukin-6, and microRNA-214 in serum from mice exposed to microgravity and radiation, with intraclass correlation coefficients > 0.75, comparable to ELISA and qPCR. More importantly, integrating the system with a convolutional neural network enabled precise bone health prediction. This platform provides a promising tool for astronaut health monitoring.
Authors
- Jiawei Zhang (ORCID: https://orcid.org/0000-0001-5774-7592)
- Yingxian Li (ORCID: https://orcid.org/0009-0003-4295-6051)
- Bingyan Li (ORCID: https://orcid.org/0000-0002-0404-7709)
- Guangming Zhou (ORCID: https://orcid.org/0000-0001-5695-2308)
- Houyu Wang (ORCID: https://orcid.org/0000-0002-5134-9881)
- Xuan Qin (ORCID: https://orcid.org/0000-0002-5763-3963)
- Yufan Ling
- Ruijie Xie (ORCID: https://orcid.org/0000-0003-2424-1282)
- Yang Yang (ORCID: https://orcid.org/0000-0002-7891-2670)
- Jianwei Li (ORCID: https://orcid.org/0000-0002-3682-6934)
- Di Fan (ORCID: https://orcid.org/0000-0001-7291-2592)
- Haoyuan Xu (ORCID: https://orcid.org/0000-0001-5946-1950)
- Yiwei Wang (ORCID: https://orcid.org/0000-0002-9528-7846)
- Yue Fan (ORCID: https://orcid.org/0009-0009-1625-2775)
- Weijia Sun
Institutions
- Tongji University (CN)
- Soochow University (CN)
- Shanghai Pulmonary Hospital (CN)
- China Astronaut Research and Training Center (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1002/advs.202507189
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- National Key Research and Development Program of China
- Shenzhen Science and Technology Innovation Program