[Diagnosis and treatment strategies of autoimmune hepatitis and future challenges].

Autoimmune hepatitis (AIH) is a kind of immune-mediated chronic liver disease, and its specific pathogenesis has not yet been fully elucidated. In recent years, the International Autoimmune Hepatitis Expert Group has revised histology and autoantibody evaluation criteria for diagnosing AIH and has clarified the definition of treatment response. The current standard treatment regimen is still glucocorticoids and azathioprine, but novel biological agents offer new therapeutic options for patients with refractory AIH. This article reviews the new progress in the diagnosis and treatment of AIH and explores the current challenges and future research directions.

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Publication Details

Journal
PubMed
Published
2025-07-20
DOI
https://doi.org/10.3760/cma.j.cn501113-20250508-00179
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
0.00
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article

[Diagnosis and treatment strategies of autoimmune hepatitis and future challenges].

Tianyang Mao, Xiaojing Ma, Xiao Xiao
PubMed
Liver Diseases and Immunity
article

[Diagnosis and treatment strategies of autoimmune hepatitis and future challenges].

Tianyang Mao, Xiaojing Ma, Xiao Xiao
article en

Abstract

Autoimmune hepatitis (AIH) is a kind of immune-mediated chronic liver disease, and its specific pathogenesis has not yet been fully elucidated. In recent years, the International Autoimmune Hepatitis Expert Group has revised histology and autoantibody evaluation criteria for diagnosing AIH and has clarified the definition of treatment response. The current standard treatment regimen is still glucocorticoids and azathioprine, but novel biological agents offer new therapeutic options for patients with refractory AIH. This article reviews the new progress in the diagnosis and treatment of AIH and explores the current challenges and future research directions.

PubMedVol. 33(7)
Shanghai Jiao Tong University (CN), Renji Hospital (CN)
Openalex Percentile: Top 71%
Liver Diseases and Immunity
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