Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Isolates from a Multicenter Study in Korea

Owing to concern that carbapenemase-producing strains among carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CRPA) isolates is on the rise, we investigated the genetic epidemiology and antimicrobial susceptibilities of clinical CRPA isolates collected in four academic hospitals in Korea. Carbapenemase genes were detected in 46 of 63 CRPA isolates (73.0%) collected between 2021 and 2024, and <i>bla</i><sub>NDM</sub> ST773 was the most common genotype (27 isolates, 42.9%), followed by <i>bla</i><sub>NDM</sub> ST644 (9 isolates, 14.3%) and <i>bla</i><sub>IMP</sub> ST235 (7 isolates, 11.1%). Overall susceptibility to ceftazidime/avibactam was only 17.5%, and none of the carbapenemase-producing isolates were susceptible to it. All ST644 strains were also resistant to aztreonam.

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Publication Details

Journal
Infection and Chemotherapy
Published
2025-01-01
DOI
https://doi.org/10.3947/ic.2025.0032
Citations
1
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
0.59

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article

Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant Pseudomonas aeruginosa Isolates from a Multicenter Study in Korea

Oh‐Hyun Cho, Tark Kim, Jongtak Jung, Hee Bong Shin et al.
1 citations
Infection and Chemotherapy
Antibiotic Resistance in Bacteria
0.59
article

Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant Pseudomonas aeruginosa Isolates from a Multicenter Study in Korea

Oh‐Hyun Cho, Tark Kim, Jongtak Jung, Hee Bong Shin, Tae Youn Choi, Yoon-Kyoung Hong, Mi‐Na Kim, Seonghee Park, Yong Pil Chong, Young Jin Choi
article en
1 citations

Abstract

Owing to concern that carbapenemase-producing strains among carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CRPA) isolates is on the rise, we investigated the genetic epidemiology and antimicrobial susceptibilities of clinical CRPA isolates collected in four academic hospitals in Korea. Carbapenemase genes were detected in 46 of 63 CRPA isolates (73.0%) collected between 2021 and 2024, and <i>bla</i><sub>NDM</sub> ST773 was the most common genotype (27 isolates, 42.9%), followed by <i>bla</i><sub>NDM</sub> ST644 (9 isolates, 14.3%) and <i>bla</i><sub>IMP</sub> ST235 (7 isolates, 11.1%). Overall susceptibility to ceftazidime/avibactam was only 17.5%, and none of the carbapenemase-producing isolates were susceptible to it. All ST644 strains were also resistant to aztreonam.

Infection and ChemotherapyVol. 57(3)
Ulsan College (KR), Soonchunhyang University (KR), Soonchunhyang University Hospital Seoul (KR), Asan Medical Center (KR), University of Ulsan (KR), Bucheon University (KR)
National Research Foundation, National Research Foundation of Korea, Ministry of Science and ICT, South Korea
Good health and well-being
Openalex Percentile: Top 32%
Antibiotic Resistance in Bacteria
0.59
DOIOpen Access PDFOpenAlex
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Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Isolates from a Multicenter Study in Korea — Oh‐Hyun Cho, Tark Kim, et al. · Infection and Chemotherapy (2025) | TGRS Research Map | TGRS