Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature
This study highlights mitochondrial dysfunction as a consistent pathological feature in JDM muscle, which may be independent of interferon-driven inflammation. These findings highlight the potential for mitochondrial-targeted therapies in JDM management and emphasise the need for further studies to explore their therapeutic value.
Authors
- Clarissa Pilkington (ORCID: https://orcid.org/0000-0003-2289-2428)
- Melissa Kartawinata (ORCID: https://orcid.org/0000-0002-9432-393X)
- Charalampia Papadopoulou (ORCID: https://orcid.org/0000-0002-1237-0557)
- Meredyth Wilkinson (ORCID: https://orcid.org/0000-0002-7972-8066)
- Lucy R. Wedderburn (ORCID: https://orcid.org/0000-0002-7495-1429)
- Ashirwad Merve (ORCID: https://orcid.org/0000-0001-9715-1849)
- Christopher B. Mahony (ORCID: https://orcid.org/0000-0003-4487-2540)
- Yvonne Glackin
- Simon Eaton (ORCID: https://orcid.org/0000-0003-0892-9204)
- Olumide Ogunbiyi (ORCID: https://orcid.org/0000-0001-5208-5526)
- Adam P. Croft (ORCID: https://orcid.org/0000-0002-9487-0511)
- Huong D. Nguyen (ORCID: https://orcid.org/0000-0003-1524-8028)
- Mario Cortina‐Borja (ORCID: https://orcid.org/0000-0003-0627-2624)
- Aris E Syntakas
- N. Evans
- Muthana Al Obaidi (ORCID: https://orcid.org/0000-0002-2144-3682)
Institutions
- Great Ormond Street Hospital (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University College London (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1016/j.ard.2025.07.015
- Citations
- 4
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Institute for Health and Care Research
- Versus Arthritis
- Medical Research Council