Intraperitoneal Perfusion with Cisplatin or Mitomycin C Improves Survival in Mice Bearing Peritoneal Metastases from Ovarian Cancer
The results suggest that intraperitoneal perfusion of cisplatin and mitomycin C can be a valuable adjuvant to cytoreductive surgery, while the addition of moderate hyperthermia did not improve efficacy. Additional studies investigating long-term outcome are necessary to determine the impact of hyperthermia as a component of the HIPEC procedure.
Authors
- Kjersti Flatmark (ORCID: https://orcid.org/0000-0001-7409-0780)
- Stein Waagene
- Theodor Malmer Herud
- Karianne G. Fleten (ORCID: https://orcid.org/0000-0003-0697-9750)
- Yvonne Andersson (ORCID: https://orcid.org/0000-0003-3528-7171)
- Emil Løvstakken
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Norwegian Cancer Society (NO)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1245/s10434-025-18025-x
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kreftforeningen
- Universitetet i Oslo