T cell-related diagnostic model and the underlying mechanism related to PRF1-mediated glycolysis in sepsis: evidences from single-cell, bulk transcriptomics, and experiment validation
A 15-gene T cell-related diagnostic model for sepsis is constructed and PRF1 is confirmed to be an effective indicator and therapeutic target for sepsis, mainly functions in glycolysis.
Authors
- Zhicheng Huang (ORCID: https://orcid.org/0000-0003-0399-9668)
- Kai Qiu (ORCID: https://orcid.org/0000-0002-6575-5346)
- Hui Chen (ORCID: https://orcid.org/0000-0002-2281-5935)
- Tian Fu
Institutions
- Zhejiang Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s40001-025-02956-y
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00