Bilirubin prevents hyperlipidaemic acute pancreatitis by inhibiting aryl hydrocarbon receptor‐mediated acinar cell pyroptosis
Our data demonstrated that bilirubin protects against HLAP by suppressing AHR-mediated pyroptosis, highlighting bilirubin modulation as a potential therapeutic target for clinical intervention.
Authors
- Wenjie Liang (ORCID: https://orcid.org/0000-0002-8770-5032)
- Jun Yang (ORCID: https://orcid.org/0000-0002-1943-3979)
- Xiaoliang Dong (ORCID: https://orcid.org/0000-0002-2158-8232)
- Bo Wu (ORCID: https://orcid.org/0000-0003-2067-9965)
- Hui Shen (ORCID: https://orcid.org/0000-0003-3408-8154)
- Hanxiao Lu
Institutions
- Jiangnan University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1111/bph.70168
- Citations
- 2
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province