Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Together, these findings reveal purinosome assembly and purine salvage as key mechanisms of cancer cell adaptation and resilience to purine shortage while identifying microtubules, MTAP, and immunoevasion deficits as therapeutic vulnerabilities.
Authors
- Daniel J. George (ORCID: https://orcid.org/0000-0003-1499-7203)
- Christopher J. Pirozzi (ORCID: https://orcid.org/0000-0003-3507-1936)
- Jiaoti Huang (ORCID: https://orcid.org/0000-0003-1195-1998)
- Cheng Su
- David Moon (ORCID: https://orcid.org/0000-0003-1620-836X)
- Xia Gao (ORCID: https://orcid.org/0000-0003-0979-9990)
- Xue Jiang (ORCID: https://orcid.org/0009-0008-1098-7204)
- Chen Jin (ORCID: https://orcid.org/0000-0001-6803-5785)
- David M. Ashley (ORCID: https://orcid.org/0000-0002-4754-5900)
- Michael A. Sun (ORCID: https://orcid.org/0000-0003-3880-4787)
- Nomingerel Tserentsoodol
- Fan Zhang (ORCID: https://orcid.org/0000-0003-3311-8294)
- Michelle Bowie
- Hong Zhang (ORCID: https://orcid.org/0009-0004-6854-8934)
- Yiping He (ORCID: https://orcid.org/0000-0003-4669-6421)
- Jianpeng Yu
- Robert Wild (ORCID: https://orcid.org/0000-0001-9182-3587)
Institutions
- Duke University (US)
- Baylor College of Medicine (US)
- Duke Medical Center (US)
- Tracon Pharmaceuticals (United States) (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- Duke University Hospital (US)
- Pediatric Brain Tumor Foundation (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1667
- Citations
- 2
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.24