Copper(I)-Catalyzed Cycloisomerization of 1<i>H</i>-Indole <i>N</i>-Tethered <i>o</i>-Alkynylnitroarenes to C2-Spiropseudoindoxyl Compounds
A protocol for the efficient and expeditious synthesis of the pentacyclic C2-spiropseudoindoxyl scaffold that relies on a copper(I)-catalyzed <i>6-endo-dig</i> cycloaddition/internal redox (IR)/anthranil formation/oxaziridine formation/ring-opening spirocyclization/reduction cascade of 1<i>H</i>-indole <i>N</i>-tethered <i>o</i>-alkynylnitroarenes is described.
Authors
- Weidong Rao (ORCID: https://orcid.org/0000-0002-6088-7278)
- Philip Wai Hong Chan (ORCID: https://orcid.org/0000-0002-8786-6143)
- Yili Shen (ORCID: https://orcid.org/0009-0001-5528-5299)
- Dandan Shang
- Jordan Diaz
- H. Ma (ORCID: https://orcid.org/0009-0006-2256-6445)
Institutions
- Nanjing Forestry University (CN)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1021/acs.orglett.5c02759
- Citations
- 1
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Australian Research Council