An antibody targeting high-molecular-weight kininogen blocks contact system activation in a model of polymicrobial sepsis
The plasma contact system was activated in the CS model of polymicrobial sepsis. Targeting HK in polymicrobial sepsis may have beneficial effects in limiting excessive coagulation and could represent a novel therapeutic avenue to promote survival in sepsis.
Authors
- Erin H. Norris (ORCID: https://orcid.org/0000-0002-4522-3537)
- Sidney Strickland (ORCID: https://orcid.org/0000-0002-3072-9244)
- Shuo Wu (ORCID: https://orcid.org/0000-0002-9443-5704)
- Marissa Calvano (ORCID: https://orcid.org/0000-0001-8863-3184)
- Ana Badimon
Institutions
- Twitter (United States) (US)
- NewYork–Presbyterian Hospital (US)
- Cornell University (US)
- Rockefeller University (US)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.jtha.2025.07.032
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00