Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection
ecDNA is an essential factor in cancer progression. We found that a group of cancer cells with ecDNA is selectively depleted after lentiviral infection. This finding provides promise for ecDNA-specific targeting, suggests the need for caution in using lentivirus, and offers alternative ways to study ecDNA.
Authors
- Anton George Henssen (ORCID: https://orcid.org/0000-0003-1534-778X)
- Qinghao Yu (ORCID: https://orcid.org/0000-0002-2151-9624)
- Dacheng Zhao (ORCID: https://orcid.org/0009-0007-1968-2063)
- Roel G.W. Verhaak (ORCID: https://orcid.org/0000-0003-2773-0436)
- Amit D. Gujar (ORCID: https://orcid.org/0000-0003-0689-6680)
- Katharina Pardon (ORCID: https://orcid.org/0009-0001-5048-3261)
- Larisa Kagermazova (ORCID: https://orcid.org/0009-0004-7494-284X)
- Jef D. Boeke (ORCID: https://orcid.org/0000-0001-5322-4946)
- Eunhee Yi (ORCID: https://orcid.org/0000-0002-7839-7795)
- Kentaro Suina (ORCID: https://orcid.org/0000-0001-7805-5480)
- Emmanuel E. Korsah (ORCID: https://orcid.org/0009-0009-8695-6639)
- Xue Jin (ORCID: https://orcid.org/0000-0003-4214-6238)
- Noah A. Dusseau (ORCID: https://orcid.org/0009-0008-2243-1318)
Institutions
- United States Food and Drug Administration (US)
- German Cancer Research Center (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- Yale University (US)
- Humboldt-Universität zu Berlin (DE)
- NYU Langone Health (US)
- Michigan United (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Amsterdam University Medical Centers (NL)
- New York University (US)
- UConn Health (US)
- Charité - Universitätsmedizin Berlin (DE)
- Brooklyn College (US)
- Michigan State University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0144
- Citations
- 1
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Elsa U. Pardee Foundation
- Cancer Research UK
- European Commission
- Deutsche Krebshilfe
- National Institutes of Health
- National Cancer Institute