Epidemiology, clinical characteristics, and outcome of enterococcal bloodstream infections in critically ill patients in China: a single-center retrospective 10-year analysis
Enterococcal bloodstream infections are a serious concern in critically ill patients, often associated with multidrug resistance (MDR) and high mortality rates. This study highlights the importance of early intervention, including source control and timely antimicrobial therapy, in improving patient outcomes. By identifying key risk factors for mortality, such as comorbidities, male sex, and delayed treatment, this research provides valuable insights for clinicians in managing these infections. Notably, the study emphasizes the crucial role of early removal of central venous catheters and targeted therapy in reducing mortality risk. These findings underscore the need for effective infection prevention strategies and timely clinical decisions in critically ill patients. This work lays the foundation for future research aimed at optimizing treatment approaches and combating the growing challenge of MDR <i>Enterococcus</i> infections in intensive care settings.
Authors
- Zihan Yi
- Ye Jin (ORCID: https://orcid.org/0009-0003-1761-7728)
- Man Huang (ORCID: https://orcid.org/0000-0002-0842-2254)
- Yue Hu (ORCID: https://orcid.org/0000-0001-6577-2536)
Institutions
- Ministry of Education (NZ)
- Ministry of Education (BD)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1128/spectrum.01067-25
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China