Epidemiology, clinical characteristics, and outcome of enterococcal bloodstream infections in critically ill patients in China: a single-center retrospective 10-year analysis

Enterococcal bloodstream infections are a serious concern in critically ill patients, often associated with multidrug resistance (MDR) and high mortality rates. This study highlights the importance of early intervention, including source control and timely antimicrobial therapy, in improving patient outcomes. By identifying key risk factors for mortality, such as comorbidities, male sex, and delayed treatment, this research provides valuable insights for clinicians in managing these infections. Notably, the study emphasizes the crucial role of early removal of central venous catheters and targeted therapy in reducing mortality risk. These findings underscore the need for effective infection prevention strategies and timely clinical decisions in critically ill patients. This work lays the foundation for future research aimed at optimizing treatment approaches and combating the growing challenge of MDR <i>Enterococcus</i> infections in intensive care settings.

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Publication Details

Journal
Microbiology Spectrum
Published
2025-08-11
DOI
https://doi.org/10.1128/spectrum.01067-25
Primary Topic
Antimicrobial Resistance in Staphylococcus
Type
article
Field-Weighted Citation Impact
0.00

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article

Epidemiology, clinical characteristics, and outcome of enterococcal bloodstream infections in critically ill patients in China: a single-center retrospective 10-year analysis

Zihan Yi, Ye Jin, Man Huang, Yue Hu
Microbiology Spectrum
Antimicrobial Resistance in Staphylococcus
article

Epidemiology, clinical characteristics, and outcome of enterococcal bloodstream infections in critically ill patients in China: a single-center retrospective 10-year analysis

Zihan Yi, Ye Jin, Man Huang, Yue Hu
article en

Abstract

Enterococcal bloodstream infections are a serious concern in critically ill patients, often associated with multidrug resistance (MDR) and high mortality rates. This study highlights the importance of early intervention, including source control and timely antimicrobial therapy, in improving patient outcomes. By identifying key risk factors for mortality, such as comorbidities, male sex, and delayed treatment, this research provides valuable insights for clinicians in managing these infections. Notably, the study emphasizes the crucial role of early removal of central venous catheters and targeted therapy in reducing mortality risk. These findings underscore the need for effective infection prevention strategies and timely clinical decisions in critically ill patients. This work lays the foundation for future research aimed at optimizing treatment approaches and combating the growing challenge of MDR <i>Enterococcus</i> infections in intensive care settings.

Microbiology SpectrumVol. 13(9)
Ministry of Education (NZ), Ministry of Education (BD), Second Affiliated Hospital of Zhejiang University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 75%
Antimicrobial Resistance in Staphylococcus
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