The efficacy of hyperthermia-based multimodal therapy is dependent on gatekeeper protein, BID
The results suggest that BID acts as a key gatekeeper molecule of apoptosis during hyperthermia-based multimodal treatment. These findings raise important questions about the underlying mechanisms of heat-induced apoptosis and its involvement in orchestrating various cellular stress pathways.
Authors
- Yong Jun Lee (ORCID: https://orcid.org/0000-0001-5914-8489)
- Xinxin Song (ORCID: https://orcid.org/0000-0003-3868-2644)
- Dong Hyun Kim (ORCID: https://orcid.org/0000-0001-5778-1264)
- Sarah Helmueller
Institutions
- Northwestern University (US)
- Cedars-Sinai Medical Center (US)
- University of Illinois Chicago (US)
- Southwestern Medical Center (US)
- McCormick (United States) (US)
- Southwestern Medical Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- International Journal of Hyperthermia
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1080/02656736.2025.2544017
- Citations
- 2
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.30