Trained human bone marrow mesenchymal stem cells restore tissue immuno-microenvironment in fulminant hepatic failure mice
T-hBMSC exhibited enhanced immunomodulation, effectively rescuing liver failure and reducing inflammation via restoring the immune-microenvironment. These findings highlighted the potential of trained immunity as a novel strategy for the treatment of liver failure.
Authors
- Bingqi Li (ORCID: https://orcid.org/0000-0002-3145-9610)
- Qian Zhou (ORCID: https://orcid.org/0000-0002-1828-4879)
- Jinjin Luo
- Jing Jiang (ORCID: https://orcid.org/0000-0001-7549-1164)
- Shiwen Ma
- Xi Chen (ORCID: https://orcid.org/0000-0003-4223-5804)
- Xi Liang (ORCID: https://orcid.org/0000-0001-7954-0111)
- Jun Li (ORCID: https://orcid.org/0000-0002-7236-8088)
- Tong Li (ORCID: https://orcid.org/0000-0003-3725-1420)
- Bing Zhu (ORCID: https://orcid.org/0000-0003-0190-6384)
- Qiang Wei (ORCID: https://orcid.org/0000-0003-1935-520X)
- Jiaojiao Xin
- Wu Xiao (ORCID: https://orcid.org/0000-0003-1810-7562)
- Dongyan Shi
- Yuheng Kong
- Xinhua Luo
- Xiaofei Zeng
Institutions
- Zunyi Medical University (CN)
- Chinese PLA General Hospital (CN)
- 302 Military Hospital of China (CN)
- National Clinical Research (US)
- National Centre for Infectious Diseases (SG)
- Guizhou Provincial People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Imperial College London (GB)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1186/s13287-025-04540-x
- Citations
- 2
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Recruitment Program of Global Experts
- Key Technologies Research and Development Program