Astrocytes promote oligodendrocyte precursor cell proliferation via Cx47<b>-</b>mediated regulation of exosome<b>-</b>derived CHI3L1 secretion.

This study reveals a novel mechanism by which ASTs regulate OPC proliferation: Through direct contact, ASTs enhance the secretion of CHI3L1-rich exosomes via Cx47, thereby converting intercellular contact signals into secretory signals that promote OPC proliferation. As a key exosomal molecule, CHI3L1 may play an important role in neural function and remyelination and warrants further investigation.