ARID1A Loss plus CD8+ T-Cell Infiltration Associate with Favorable Clinical Outcomes in Urothelial Carcinoma
The combination of ARID1A loss plus CD8+ T-cell infiltration indicated a favorable prognosis and responsiveness to both chemotherapy and immunotherapy. These findings provide valuable insights for developing novel therapeutic strategies and improving treatment stratification for urothelial carcinoma.
Authors
- Kaifeng Jin (ORCID: https://orcid.org/0000-0001-9867-6516)
- Weijuan Zhang (ORCID: https://orcid.org/0000-0003-3494-3114)
- Zewei Wang (ORCID: https://orcid.org/0000-0002-8833-3541)
- Yuan Chang (ORCID: https://orcid.org/0000-0003-2042-9317)
- Zhaopei Liu (ORCID: https://orcid.org/0000-0002-5288-5037)
- Yawei Ding (ORCID: https://orcid.org/0000-0002-2879-3642)
- Yuzhen Wu (ORCID: https://orcid.org/0009-0003-6616-653X)
- Jiejie Xu (ORCID: https://orcid.org/0000-0001-7431-9063)
- Lingkai Zhang (ORCID: https://orcid.org/0009-0001-0405-057X)
- Xiaohe Su (ORCID: https://orcid.org/0009-0006-4951-2236)
- Han Zeng (ORCID: https://orcid.org/0000-0001-6486-2038)
- Yu Zhu (ORCID: https://orcid.org/0000-0002-3332-5202)
- Le Xu (ORCID: https://orcid.org/0009-0003-6751-9261)
- Hailong Liu (ORCID: https://orcid.org/0000-0003-2488-1239)
- Jiaxing Sun (ORCID: https://orcid.org/0000-0002-2808-0079)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Army Medical University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
- Fudan University Shanghai Cancer Center (CN)
- Xinqiao Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0816
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Gilead Sciences
- Natural Science Foundation of Shanghai
- Shanghai Anti-Cancer Association
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Education Development Foundation
- Fudan University
- Shanghai Municipal Education Commission
- Shanghai Municipal Health Bureau
- Army Medical University