Interleukin-10 augments human endogenous retroviral E1B variant of cd5 in aged T cells
IL-10-driven exon switching alters CD5 expression in aged T cells, increasing E1B and decreasing E1A through CEBP-β regulation. These findings reveal a novel mechanism underlying fundamental immune aging and suggest potential targets for immune modulation. These insights may have clinical implications in chronic inflammatory diseases, autoimmune disorders, and cancer therapies.
Authors
- Chandra Prakash Chaturvedi (ORCID: https://orcid.org/0000-0002-4017-430X)
- Shobhita Katiyar (ORCID: https://orcid.org/0000-0001-9193-4068)
- Arunim Shah (ORCID: https://orcid.org/0000-0002-7107-7457)
- Amit Kumar Kureel (ORCID: https://orcid.org/0000-0001-6988-3786)
- Kulwant Singh (ORCID: https://orcid.org/0000-0002-5635-9675)
- Ambak Kumar (ORCID: https://orcid.org/0000-0002-6564-6342)
- Bharat Singh
- S. Laxmi Kumari
Institutions
- Motilal Nehru National Institute of Technology (IN)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
Publication Details
- Journal
- Blood Research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1007/s44313-025-00080-8
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
- Motilal Nehru National Institute of Technology Allahabad