Intestinal luminal polyamines support the gut colonization of enteric bacterial pathogens by modulating flagellar motility and nitrate respiration
Microbiota-derived metabolites play crucial roles in gastrointestinal infections caused by enteric pathogens. One notable example is short-chain fatty acids, such as acetate, propionate, and butyrate, which are beneficial for health and protective against infection. This study highlights that the gut microbiota‒derived polyamine spermidine drives luminal growth of enteric bacterial pathogens. The findings suggest that higher luminal levels of polyamines may be a risk factor for enteric infections. Therefore, regulating luminal polyamines could represent a promising therapeutic intervention for gastrointestinal infections.
Authors
- Tsuyoshi Miki (ORCID: https://orcid.org/0000-0003-3563-2991)
- Takemitsu Furuchi (ORCID: https://orcid.org/0000-0001-6486-8720)
- Shin Kurihara (ORCID: https://orcid.org/0000-0002-2756-4629)
- Yuta Ami
- Takeshi Haneda (ORCID: https://orcid.org/0000-0002-7506-4530)
- Takeshi Uemura
- Tohru Minamino (ORCID: https://orcid.org/0000-0002-8175-1951)
- Yun‐Gi Kim (ORCID: https://orcid.org/0000-0003-4251-1848)
- Masahiro Ito (ORCID: https://orcid.org/0000-0002-6489-0431)
- Nobuhiko Okada
Institutions
- Josai University (JP)
- Ube Frontier University (JP)
- Kitasato University (JP)
- Kindai University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- mBio
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1128/mbio.01786-25
- Citations
- 3
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Japan Society for the Promotion of Science