Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation
This study highlights the crucial role of transcription factor binding, such as EGR1, to enhancer regions, which may be key to establishing cell-type-specific gene regulation in neurons.
Authors
- Michael A. Fox (ORCID: https://orcid.org/0000-0002-1649-7782)
- Gabriela L. Carrillo
- Xiguang Xu (ORCID: https://orcid.org/0000-0001-6862-7545)
- Liduo Yin (ORCID: https://orcid.org/0000-0003-2310-9511)
- Hehuang Xie (ORCID: https://orcid.org/0000-0001-5739-1653)
- Yupeng Cun (ORCID: https://orcid.org/0000-0002-4241-8099)
- Xuemei Lu (ORCID: https://orcid.org/0000-0001-6044-6002)
- Lin Yu
- Benjamin Conacher
Institutions
- Kunming Institute of Zoology (CN)
- Carilion Roanoke Memorial Hospital (US)
- Virginia–Maryland College of Veterinary Medicine (US)
- Biomedical Research Institute (US)
- Children's Hospital of Chongqing Medical University (CN)
- University of Chinese Academy of Sciences (CN)
- Carilion Clinic (US)
- Virginia Tech (US)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1186/s12915-025-02357-x
- Citations
- 2
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Edward Via College of Osteopathic Medicine
- National Natural Science Foundation of China
- State Key Laboratory of Genetic Resources and Evolution
- National Institutes of Health
- Virginia-Maryland College of Veterinary Medicine
- National Key Research and Development Program of China
- National Institute of Neurological Disorders and Stroke