Uncovering the mechanistic basis of <i>Rheum palmatum</i> L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular docking, and experimental validation
Rhubarb significantly reduces renal impairment, fibrosis, inflammation, and apoptosis through the NF-κB pathway, supporting its traditional use and potential as an adjunct therapy for CKD.
Authors
- Jing Ma (ORCID: https://orcid.org/0000-0003-1075-7624)
- Lei Wu (ORCID: https://orcid.org/0000-0002-6435-5041)
- Guang Ta
- Zhen Wei (ORCID: https://orcid.org/0000-0001-6273-3232)
- Siwei Li (ORCID: https://orcid.org/0000-0002-9586-3241)
- Wenjing He (ORCID: https://orcid.org/0000-0002-9429-1894)
- Dan Lu (ORCID: https://orcid.org/0000-0003-4718-3564)
- Shijie Han (ORCID: https://orcid.org/0000-0002-3643-050X)
Institutions
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1080/13880209.2025.2543829
- Citations
- 4
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 7.00