A Multicenter, Retrospective Study Comparing Immunosuppressive Therapy Combined with Eltrombopag to Immunosuppressive Therapy Alone as Front-Line Treatment for Pediatric Severe Aplastic Anemia
EPAG+IST induced a faster response compared to IST alone without increasing toxic effects, but EPAG did not confer additional benefits regarding OS or relapse rates in children. Notably, older age at diagnosis was significantly associated with improved response rates in the EPAG+IST group.
Authors
- Mehmet Fatih Orhan (ORCID: https://orcid.org/0000-0001-8081-6760)
- Fatih Erbey (ORCID: https://orcid.org/0000-0002-4475-0407)
- Talia İleri (ORCID: https://orcid.org/0000-0002-0244-353X)
- Mehmet Ertem (ORCID: https://orcid.org/0000-0002-8173-7885)
- Sinan Akbayram (ORCID: https://orcid.org/0000-0001-7410-4310)
- Davut Albayrak (ORCID: https://orcid.org/0000-0002-7947-3817)
- Mustafa Büyükavcı (ORCID: https://orcid.org/0000-0002-9054-3134)
- Melek Işık (ORCID: https://orcid.org/0000-0002-7503-303X)
- Didem Atay (ORCID: https://orcid.org/0000-0003-3040-1959)
- Neşe Yaralı (ORCID: https://orcid.org/0000-0001-5488-2385)
- Selin Aytaç (ORCID: https://orcid.org/0000-0003-2192-298X)
- Alper Özcan (ORCID: https://orcid.org/0000-0002-6100-1205)
- Şebnem Yılmaz (ORCID: https://orcid.org/0000-0001-7874-3734)
- Gonca Kaçar
- Hasan Fatih Çakmaklı (ORCID: https://orcid.org/0000-0003-0152-1564)
- Nihal Karadaş (ORCID: https://orcid.org/0000-0002-0019-7347)
- İbrahim Eker (ORCID: https://orcid.org/0000-0002-1880-546X)
- Hilmi Apak (ORCID: https://orcid.org/0000-0003-4102-6402)
- Hale Ören (ORCID: https://orcid.org/0000-0001-5760-8007)
- Musa Karakükçü (ORCID: https://orcid.org/0000-0003-2015-3541)
- Tuba Hilkay Karapınar (ORCID: https://orcid.org/0000-0002-4714-332X)
- Deniz Yılmaz Karapınar (ORCID: https://orcid.org/0000-0002-1637-4678)
- Tekin Aksu (ORCID: https://orcid.org/0000-0003-4968-109X)
- Tiraje Çelkan (ORCID: https://orcid.org/0000-0001-7287-1276)
- Şule Ünal (ORCID: https://orcid.org/0000-0002-3842-8788)
- Aysha Gadashova (ORCID: https://orcid.org/0000-0002-7774-1136)
Institutions
- Sakarya University (TR)
- Ministry of Health (TR)
- Izmir University (TR)
- Koç University (TR)
- Ankara University (TR)
- University of Health Science (KH)
- Dokuz Eylül University (TR)
- Ege University (TR)
- Turkish Society of Hematology (TR)
- Dr. Behçet Uz Çocuk Hastalıkları Hastanesi (TR)
- Memorial Ankara Hospital (TR)
- Necmettin Erbakan University (TR)
- Istanbul University-Cerrahpaşa (TR)
- Samsun University (TR)
- Başkent University Hospital (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Afyonkarahisar Sağlık Bilimleri Üniversitesi
- Afyon Kocatepe University (TR)
- Gaziantep University (TR)
- Hacettepe University (TR)
- University of Health Sciences Antigua (AG)
- Erciyes University (TR)
Publication Details
- Journal
- Turkish Journal of Hematology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.4274/tjh.galenos.2025.2025.0245
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00