Integrative single‐cell transcriptomic analysis deciphers heterogeneous characteristics of gastrointestinal tract cancer
A comprehensive single-cell atlas of gastrointestinal tract cancer (GIC) was constructed. GICs exhibit distinct epithelial features and specific tumour microenvironment (TME) patterns, forming diverse niches. GC and EC exhibiting metaplastic features show elevated metabolism-associated signatures and share similarities with CRC.
Authors
- Zhihui Xiu (ORCID: https://orcid.org/0000-0002-4336-9276)
- Huanming Yang (ORCID: https://orcid.org/0000-0002-0858-3410)
- Tong Li (ORCID: https://orcid.org/0000-0001-5947-1884)
- Kui Wu (ORCID: https://orcid.org/0000-0002-6857-7231)
- Xin Jin (ORCID: https://orcid.org/0000-0001-6461-6005)
- Ming Liu (ORCID: https://orcid.org/0000-0001-7144-2891)
- Hang Su (ORCID: https://orcid.org/0000-0001-6291-0948)
- Chuwen Sun
Institutions
- BGI Group (China) (CN)
- Jinggangshan University (CN)
- Harbin Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Education Department of Heilongjiang Province (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/ctm2.70415
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province