C–F Bond Functionalization: Controlled Didefluorination of <i>o</i>-Trifluoromethyl Benzylamines
Organofluorine compounds are widely used but pose environmental concerns. We report a base-mediated didefluorination of <i>o</i>-trifluoromethyl benzylamines via difluoroquinone methide intermediates, yielding monofluorinated tricyclic 2<i>H</i>-imidazoles. This efficient method showcases a broad substrate scope and offers mechanistic insight through a 1,4-elimination pathway of two fluoride ions.
Authors
- Seema Dhiman (ORCID: https://orcid.org/0000-0002-0897-9925)
- Mahesh Kumar Ravva (ORCID: https://orcid.org/0000-0001-9619-0176)
- Mahipal Yadav
- Rushikesh R. Kusmude
- Siddhant A. Kale
Institutions
- University of Delhi (IN)
- SRM University (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1021/acs.orglett.5c02828
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- SRM Institute of Science and Technology