Fertilin peptide decreases embryo resorption and improves live birth rate in mouse
This study demonstrates that Fertilin peptide accelerates embryo development in vitro, reduces the resorption rate in utero, and increases the live birth rate in mice. In the mouse model, Fertilin appears to be the first molecule able to significantly reduce miscarriage in vivo and improve live birth rate. The human molecule is currently being evaluated in an ongoing prospective, randomized, multicenter clinical trial (NCT:04954274).
Authors
- Sophie Favier (ORCID: https://orcid.org/0000-0003-0257-7076)
- Isabelle Lagoutte (ORCID: https://orcid.org/0000-0001-9291-2207)
- Daniel Vaiman (ORCID: https://orcid.org/0000-0002-1915-0717)
- Rémi Pierre (ORCID: https://orcid.org/0000-0002-2008-9546)
- Audrey L'Hostis
- Éric Vicaut (ORCID: https://orcid.org/0000-0001-6303-8557)
- Jean Philippe Wolf
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Cochin (FR)
Publication Details
- Journal
- F&S Science
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.xfss.2025.08.001
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00