Isolation of phytochemicals and exploration the mechanism of Dolichandrone spathacea in the treatment of chronic bronchitis by integrating network pharmacology, molecular docking, and experimental validation
This study systematically investigated the phytoconstituents, core target genes, and key mechanisms of D. spathacea in the treatment of chronic bronchitis. It highlights the role of this species in modulating the TNF and IL-17 signaling pathways in CB therapy. The findings suggest that D. spathacea exhibits significant anti-inflammatory effects on CB, providing robust scientific evidence and novel insights for further research on chronic bronchitis.
Authors
- Yunhan Wang (ORCID: https://orcid.org/0000-0001-8823-0326)
- Su-Jung Hsu
- Man-Hsiu Chu
- Duyen Thi My Huynh (ORCID: https://orcid.org/0000-0003-3306-3051)
- Ching‐Kuo Lee (ORCID: https://orcid.org/0000-0003-2827-396X)
- Dang-Khoa Nguyen (ORCID: https://orcid.org/0000-0002-6681-7609)
- Ta-Wei Liu (ORCID: https://orcid.org/0000-0002-4286-2210)
- Shumei Wang (ORCID: https://orcid.org/0000-0002-3338-2987)
- Thuy-Tien Thi Phan
- Truc-Ly Thi Duong (ORCID: https://orcid.org/0009-0002-2063-5938)
- Quoc-Dung Tran Huynh (ORCID: https://orcid.org/0009-0005-0908-3433)
Institutions
- National Taiwan University (TW)
- Can Tho University (VN)
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- Bình Dương University (VN)
- Taipei Medical University (TW)
- National Taipei University (TW)
Publication Details
- Journal
- Botanical studies
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s40529-025-00464-0
- Citations
- 1
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Taipei Medical University