Identifying Risk Factors and Constructing Predictive Models for Wearing‐Off and Dyskinesia in Chinese Patients With Parkinson's Disease on Long‐Term Levodopa Therapy
Our findings suggest that the prevalence of motor complications during long-term LD treatment is relatively high among PD patients in China, with WO occurring more commonly than dyskinesia. Younger age at PD onset, higher LEDD, more severe disease, and akinetic-rigid subtype are key predictors of motor complications. The predictive models developed in this study could serve as a potential tool to assist clinicians in identifying patients at higher risk for WO and dyskinesia, and may support personalized treatment optimization.
Authors
- Chong Shi
- Jiaqi Chen (ORCID: https://orcid.org/0009-0006-3602-0291)
- Jichen Du (ORCID: https://orcid.org/0009-0000-1385-1347)
- Jing Zhao (ORCID: https://orcid.org/0000-0003-0158-5330)
- Zhirong Wan
- Yanhong Wang (ORCID: https://orcid.org/0000-0001-8152-0574)
- Jia Chen (ORCID: https://orcid.org/0009-0005-0957-1744)
- Shuang Ma (ORCID: https://orcid.org/0000-0001-7125-5279)
- Peifu Wang (ORCID: https://orcid.org/0000-0003-4993-1386)
- Jilai Li
- Yuansheng Gao
Institutions
- Beijing Geriatric Hospital (CN)
- Aerospace Center Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/cns.70544
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Aerospace Center Hospital