Outcomes of patients with newly diagnosed acute myeloid leukemia with <i>FLT3</i>‐tyrosine kinase domain mutations: Prognostic implications of <i>NPM1</i> co‐mutation
FLT3-TKD<sup>mut</sup> AML commonly harbors NPM1 co-mutation, which has key prognostic implications. Lack of NPM1 co-mutation portends a poor prognosis, and allogenic stem cell transplantation should be strongly considered for patients in first remission.
Authors
- Courtney Denton Dinardo (ORCID: https://orcid.org/0000-0001-9003-0390)
- Wei‐Ying Jen (ORCID: https://orcid.org/0000-0002-9339-3362)
- Sankalp Arora (ORCID: https://orcid.org/0000-0002-8162-4119)
- Tapan Mahendra Kadia (ORCID: https://orcid.org/0000-0002-9892-9832)
- Naval Guastad Daver (ORCID: https://orcid.org/0000-0001-7103-373X)
- Musa E. Yilmaz (ORCID: https://orcid.org/0000-0002-4498-4895)
- Koichi Takahashi (ORCID: https://orcid.org/0000-0002-8027-9659)
- Gautam M. Borthakur (ORCID: https://orcid.org/0000-0001-7679-6453)
- Elizabeth J. Shpall (ORCID: https://orcid.org/0000-0003-3947-4126)
- Sanam Loghavi (ORCID: https://orcid.org/0000-0001-8980-3202)
- Guillermo Garcia‐Manero (ORCID: https://orcid.org/0000-0002-3631-2482)
- Uday Popat (ORCID: https://orcid.org/0000-0002-7592-2224)
- Farhad Ravandi
- Hussein A. Abbas (ORCID: https://orcid.org/0000-0003-2946-3562)
- Kapil N. Bhalla (ORCID: https://orcid.org/0000-0001-5209-5126)
- Michael Andreeff (ORCID: https://orcid.org/0000-0002-1144-1958)
- Ghayas C. Issa
- Jayastu Senapati (ORCID: https://orcid.org/0000-0002-6831-2567)
- Betül Oran (ORCID: https://orcid.org/0000-0003-1264-5968)
- Naveen Pemmaraju (ORCID: https://orcid.org/0000-0002-1670-6513)
- Hagop M. Kantarjian (ORCID: https://orcid.org/0000-0002-1908-3307)
- Nicholas James Short (ORCID: https://orcid.org/0000-0002-2983-2738)
- Joseph Jabbour
- Indraneel Deshmukh
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Cancer
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1002/cncr.70032
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- University of Texas MD Anderson Cancer Center