Agrimonolide from Agrimonia pilosa Ledeb attenuates cholestatic liver injury and macrophage infiltration via the inhibition of bile acid excretion transporters
AM has therapeutic potential in cholestatic liver diseases by ameliorating ductular proliferation, fibrosis, and macrophage infiltration through the inhibition of bile acid excretion transporters.
Authors
- Dongyu Bai (ORCID: https://orcid.org/0000-0003-4647-217X)
- Ya Zhou (ORCID: https://orcid.org/0000-0002-1960-8900)
- Cheng Guo (ORCID: https://orcid.org/0000-0002-0762-8496)
- Heng Yan (ORCID: https://orcid.org/0000-0002-9593-5954)
- Keyuan Chen (ORCID: https://orcid.org/0000-0001-6197-5045)
- Fang Yang (ORCID: https://orcid.org/0000-0003-4054-0389)
- Quanjun Yang (ORCID: https://orcid.org/0000-0003-0279-8784)
- Lei Jing (ORCID: https://orcid.org/0000-0003-4176-1079)
- Yi Zhun Zhu (ORCID: https://orcid.org/0000-0001-7700-8041)
- Jiaqi Liu (ORCID: https://orcid.org/0000-0001-6526-8655)
- Leng Han
Institutions
- Macau University of Science and Technology (MO)
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.intimp.2025.115186
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- School of Medicine, Shanghai Jiao Tong University