Corneal neurotization meets COVID-19: a case report of minimally invasive corneal neurotization complicated by COVID-19-related keratitis
This study presents the first documented case of COVID-19-related NK following MICN established as a diagnosis of exclusion. This case underscores the critical need for comprehensive differential diagnosis to rule out infectious etiologies in post-MICN keratitis, ultimately leading to a diagnosis of exclusion for COVID-19-induced disease. The diagnostic approach outlined may offer valuable insights for similar presentations. After a protracted clinical course, the patient ultimately achieved restoration of corneal sensation and reinnervation, demonstrating the preserved regenerative potential of MICN-reconstructed neural pathways even after severe viral infection.
Authors
- Si-yue Zhuang (ORCID: https://orcid.org/0009-0009-9225-2187)
- Qiaoran Qi (ORCID: https://orcid.org/0000-0002-3304-8284)
- Jiaying Zhang (ORCID: https://orcid.org/0009-0000-6855-7823)
- Li Jin (ORCID: https://orcid.org/0000-0002-7168-4679)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Journal of Ophthalmic Inflammation and Infection
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1186/s12348-025-00521-6
- Primary Topic
- Retinal and Optic Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Manchester
- National Natural Science Foundation of China