Corneal neurotization meets COVID-19: a case report of minimally invasive corneal neurotization complicated by COVID-19-related keratitis

This study presents the first documented case of COVID-19-related NK following MICN established as a diagnosis of exclusion. This case underscores the critical need for comprehensive differential diagnosis to rule out infectious etiologies in post-MICN keratitis, ultimately leading to a diagnosis of exclusion for COVID-19-induced disease. The diagnostic approach outlined may offer valuable insights for similar presentations. After a protracted clinical course, the patient ultimately achieved restoration of corneal sensation and reinnervation, demonstrating the preserved regenerative potential of MICN-reconstructed neural pathways even after severe viral infection.

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Publication Details

Journal
Journal of Ophthalmic Inflammation and Infection
Published
2025-08-09
DOI
https://doi.org/10.1186/s12348-025-00521-6
Primary Topic
Retinal and Optic Conditions
Type
article
Field-Weighted Citation Impact
0.00

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article

Corneal neurotization meets COVID-19: a case report of minimally invasive corneal neurotization complicated by COVID-19-related keratitis

Si-yue Zhuang, Qiaoran Qi, Jiaying Zhang, Li Jin
Journal of Ophthalmic Inflammation and Infection
Retinal and Optic Conditions
article

Corneal neurotization meets COVID-19: a case report of minimally invasive corneal neurotization complicated by COVID-19-related keratitis

Si-yue Zhuang, Qiaoran Qi, Jiaying Zhang, Li Jin
article en

Abstract

This study presents the first documented case of COVID-19-related NK following MICN established as a diagnosis of exclusion. This case underscores the critical need for comprehensive differential diagnosis to rule out infectious etiologies in post-MICN keratitis, ultimately leading to a diagnosis of exclusion for COVID-19-induced disease. The diagnostic approach outlined may offer valuable insights for similar presentations. After a protracted clinical course, the patient ultimately achieved restoration of corneal sensation and reinnervation, demonstrating the preserved regenerative potential of MICN-reconstructed neural pathways even after severe viral infection.

Journal of Ophthalmic Inflammation and InfectionVol. 15(1)
Shanghai Jiao Tong University (CN), Shanghai Ninth People's Hospital (CN), Shanghai Institute of Hematology (CN), Shanghai Clinical Research Center (CN)
University of Manchester, National Natural Science Foundation of China
Openalex Percentile: Top 69%
Retinal and Optic Conditions
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Corneal neurotization meets COVID-19: a case report of minimally invasive corneal neurotization complicated by COVID-19-related keratitis — Si-yue Zhuang, Qiaoran Qi, et al. · Journal of Ophthalmic Inflammation and Infection (2025) | TGRS Research Map | TGRS