Protocol for synthesizing both racemic and chiral allenylsilanes through copper-catalyzed silylation of propargyl dichlorides

Chiral allenylsilanes serve as crucial intermediates in the synthesis of complex pharmaceutical molecules and natural products. Here, we present a protocol for synthesizing both racemic and chiral allenylsilanes through copper-catalyzed silylation of propargyl dichlorides. We describe steps for the SN₂' propargyl silylation reaction between propargyl dichlorides and a silylboronate, followed by the purification of the products. The obtained optically active chloro-substituted allenylsilane products can be readily transformed into various useful allene derivatives, demonstrating the high synthetic value of this methodology. For complete details on the use and execution of this protocol, please refer to Liu et al.¹.