L-3n-butylphthalide maintains BBB permeability and attenuates cerebral ischemia-reperfusion injury in rats by increasing PGC-1 <i>α</i> levels
The present study demonstrates that NBP plays a role in maintaining the stability of the BBB and attenuates CIRI by increasing PGC-1<i>α</i> levels as well as by increasing the levels of vascular endothelial cells and TJ markers.
Authors
- Haishan Tian (ORCID: https://orcid.org/0000-0002-2887-6026)
- Xiangsong Shi (ORCID: https://orcid.org/0000-0002-6743-1986)
- Li‐Ling Wu (ORCID: https://orcid.org/0000-0002-2293-6999)
- Yu Wang (ORCID: https://orcid.org/0000-0001-8826-7911)
Institutions
- Xuzhou Medical College (CN)
- Fudan University (CN)
- Second People’s Hospital of Huai’an (CN)
- Zhongshan Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
Publication Details
- Journal
- International Journal of Neuroscience
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1080/00207454.2025.2545534
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00