CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model
Our findings suggest that CD24a may regulate immune suppression within the TNBC TME. Targeting CD24a enhances macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses and is associated with a shift in the TME toward a more immunogenic state, thereby suppressing tumor growth. These results may support CD24 as a promising immunotherapeutic target for TNBC.
Authors
- Lu‐Hai Wang (ORCID: https://orcid.org/0000-0003-0050-8560)
- Shih‐Hsuan Chan (ORCID: https://orcid.org/0000-0002-8703-5139)
- Ching‐Yu Lin (ORCID: https://orcid.org/0000-0002-7144-0383)
- Hsuan-Jung Tseng
Institutions
- China Medical University (TW)
- Tzu Chi University (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1186/s12929-025-01165-3
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Ministry of Education
- Academia Sinica
- Ministry of Education, India
- China Medical University
- China Medical University, Taiwan
- National Science and Technology Council