Pulmonary hypertension, inhaled nitric oxide, and retinopathy of prematurity: evidence from the U.S. national database

Premature infants diagnosed with pulmonary hypertension are at increased risk for ROP. Severe ROP is less encountered when inhaled nitric oxide was used in this vulnerable population. This is the first study to assess the interaction between pulmonary hypertension, its treatment, and the development of ROP in premature infants. The study suggests the need for future studies to assess the efficacy of early use of vascular modulators in mitigating the risk of ROP.