Cinnamoylphenethyl amides from <i>fissistigma bracteolatum</i> and their anti-inflammatory activities
Two new (<b>1</b>-<b>2</b>) and six known (<b>3</b>-<b>8</b>) cinnamoylphenethyl amides were isolated from <i>Fissistigma bracteolatum</i>. The structural configurations of <b>1</b> and <b>2</b> were determined through comprehensive spectroscopic characterisation, with mainly by NMR data analyses. Compounds <b>1</b>-<b>8</b> were assessed for the suppression on NO production. Among these, compounds <b>4</b>-<b>5</b> revealed inhibitory effects with IC<sub>50</sub>: 1.45 ± 0.16 and 21.46 ± 1.33 μM, respectively, indicating potent and moderate activity profiles.
Authors
- Yao-Yao Jia
- Jinfeng Xue (ORCID: https://orcid.org/0000-0003-1901-3912)
- Yan‐Jun Sun (ORCID: https://orcid.org/0000-0002-9074-7591)
- Yanle Zhi (ORCID: https://orcid.org/0000-0001-6066-2231)
- Guosheng Li (ORCID: https://orcid.org/0000-0003-3458-3294)
- Zhen‐Zhu Zhao (ORCID: https://orcid.org/0000-0001-7961-4694)
- Gui‐Min Xue (ORCID: https://orcid.org/0000-0002-5919-524X)
- Jing-Wei Lei
- Hui Chen (ORCID: https://orcid.org/0000-0001-9326-6649)
- Dong‐Rong Zhu (ORCID: https://orcid.org/0000-0002-7098-4055)
Institutions
- Tianjin University of Technology (CN)
- Taizhou Second People's Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1080/14786419.2025.2542256
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China