Comparison of cilomilast, tadalafil, and both drug combinations in the treatment of monocrotaline-induced pulmonary arterial hypertension in rats
CIL alone had no significant effect on PAH progression, but its combination with TAD improved inflammation scores and NO levels. These findings suggest that targeting inflammation alongside vasodilation may offer therapeutic benefits in PAH. Further studies with different doses and PAH models are recommended.
Authors
- Azibe Yıldız (ORCID: https://orcid.org/0000-0001-5686-7867)
- Ahmet Ulu (ORCID: https://orcid.org/0000-0002-4447-6233)
- Hakan Parlakpınar (ORCID: https://orcid.org/0000-0001-9497-3468)
- Onural Özhan (ORCID: https://orcid.org/0000-0001-9018-7849)
- Zeynep Küçükakçalı (ORCID: https://orcid.org/0000-0001-7956-9272)
- Burhan Ateş (ORCID: https://orcid.org/0000-0001-6080-229X)
- Necip Ermiş (ORCID: https://orcid.org/0000-0001-6781-7478)
- Nigar Vardı (ORCID: https://orcid.org/0000-0003-0576-1696)
- Ahmet Acet (ORCID: https://orcid.org/0000-0003-1131-1878)
- Zeynep Ulutas (ORCID: https://orcid.org/0000-0002-5072-2031)
Institutions
- Inonu University (TR)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1186/s12872-025-05065-0
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00