DHCR24 overexpression is involved in lipid metabolic reprogramming to drive cervical cancer malignant progression and is associated with immune microenvironment
We hypothesized that DHCR24 is involved in reprogramming lipid metabolism, especially the cholesterol pathway, to promote tumor progression in cervical cancer and correlates with the tumor-infiltrating immune microenvironment. DHCR24 is a biomarker that predicts the progression and prognosis of cervical cancer and is one of the potential targets for cervical cancer therapy.
Authors
- Qin Yao (ORCID: https://orcid.org/0000-0003-1546-1048)
- Lin Cheng (ORCID: https://orcid.org/0000-0003-3825-5378)
- Junqi He
- Yulong Chen (ORCID: https://orcid.org/0000-0003-2918-9137)
- Yuance Xu
- Yan Xu (ORCID: https://orcid.org/0000-0002-9596-2979)
- Zhuo Li (ORCID: https://orcid.org/0000-0003-3453-5903)
- Donglin Sun
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1186/s12885-025-14663-2
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Chinese Society of Clinical Oncology