Suboptimal concentrations of isavuconazole in critically ill patients treated for mold infections: a population pharmacokinetic analysis
Isavuconazole exposure in the ICU was suboptimal with high pharmacokinetic variability. Pending external validation, isavuconazole concentrations should be monitored, and higher dosing regimens considered at treatment initiation.
Authors
- Romain Sonneville (ORCID: https://orcid.org/0000-0003-0245-309X)
- Sébastien Bailly (ORCID: https://orcid.org/0000-0002-2179-4650)
- Christine Bonnal (ORCID: https://orcid.org/0000-0003-3030-5318)
- Paul-Henri Wicky (ORCID: https://orcid.org/0000-0002-1105-4667)
- Michaël Thy (ORCID: https://orcid.org/0000-0001-9366-505X)
- Charlotte Rabault
- Étienne de Montmollin (ORCID: https://orcid.org/0000-0001-6379-1928)
- Minh Lê (ORCID: https://orcid.org/0000-0002-4670-8288)
- Lila Bouadma (ORCID: https://orcid.org/0000-0002-6849-7266)
- Jean-François Timsit
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Délégation Paris 5 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1080/17425255.2025.2545920
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00