Risk factors for failure of distal femoral nonunion repair

Approximately 1 in 6 patients required additional nonunion surgery. In unadjusted analyses, initial high-energy injuries and more prior surgeries were associated with increased odds for additional nonunion surgery, suggesting that the severity of the initial injury is associated with subsequent nonunion treatment outcomes. The current study findings suggest that distal femoral nonunion repair should be based on revision fixation using augmented lateral locking plate (dual-plate or nail-plate) or blade plate constructs. However, these findings are based on unadjusted comparisons. Larger studies with sufficient power to correct or stratify for confounding are needed to further define optimal treatment.

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Publication Details

Journal
European Journal of Orthopaedic Surgery & Traumatology
Published
2025-08-10
DOI
https://doi.org/10.1007/s00590-025-04460-9
Primary Topic
Bone fractures and treatments
Type
article
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article

Risk factors for failure of distal femoral nonunion repair

Devon T. Brameier, Stein J. Janssen, Noa H. M. Ponds, Peter Kloen et al.
European Journal of Orthopaedic Surgery & Traumatology
Bone fractures and treatments
article

Risk factors for failure of distal femoral nonunion repair

Devon T. Brameier, Stein J. Janssen, Noa H. M. Ponds, Peter Kloen, Robert Kaspar Wagner, Jacob S.W. Borgida, Thuan V. Ly, Michael J. Weaver, Jochem H. Raats, Mitchel B Harris
article en

Abstract

Approximately 1 in 6 patients required additional nonunion surgery. In unadjusted analyses, initial high-energy injuries and more prior surgeries were associated with increased odds for additional nonunion surgery, suggesting that the severity of the initial injury is associated with subsequent nonunion treatment outcomes. The current study findings suggest that distal femoral nonunion repair should be based on revision fixation using augmented lateral locking plate (dual-plate or nail-plate) or blade plate constructs. However, these findings are based on unadjusted comparisons. Larger studies with sufficient power to correct or stratify for confounding are needed to further define optimal treatment.

European Journal of Orthopaedic Surgery & TraumatologyVol. 35(1)
Massachusetts General Hospital (US), Center for Orthopaedics (US), Amsterdam University Medical Centers (NL)
Good health and well-being
Openalex Percentile: Top 72%
Bone fractures and treatments
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Risk factors for failure of distal femoral nonunion repair — Devon T. Brameier, Stein J. Janssen, et al. · European Journal of Orthopaedic Surgery & Traumatology (2025) | TGRS Research Map | TGRS