Biological behavior of DCIS with or without microinvasion. Same and different
Our data shows that biological behavior of DCIS with microinvasive foci per se does not differ from pure DCIS in TTE. However, in-situ or invasive recurrences (total or ipsilateral) occur more often in microinvasive DCIS with extensive disease, with nuclear high grade, present necrosis, with narrow resection margins and in younger age in follow-up. These data warrant for further studies to understand the biology of DCIS with microinvasion and to evaluate specific therapy options different from pure DCIS potentially involving adjuvant modalities.
Authors
- Umberto Macciò (ORCID: https://orcid.org/0000-0003-3253-3787)
- Bärbel Papassotiropoulos
- Zsuzsanna Varga (ORCID: https://orcid.org/0000-0002-2855-983X)
- Isabell Witzel (ORCID: https://orcid.org/0000-0002-8734-4521)
- Heike Frauchiger-Heuer (ORCID: https://orcid.org/0000-0002-2311-5412)
- Tamara Rordorf
- Constanze Elfgen (ORCID: https://orcid.org/0000-0001-6092-6612)
- Hisham Fansa (ORCID: https://orcid.org/0000-0003-4532-8408)
- Claudia Linsenmeier
- Lisa Scheidegger
- Esther Birindelli
Institutions
- Witten/Herdecke University (DE)
- University Hospital of Zurich (CH)
- Breast Center (CH)
- Spital Zollikerberg (CH)
Publication Details
- Journal
- Human Pathology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.humpath.2025.105902
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00