A Micropeptide Killswitch May Shed Light on Condensate Formation in Cancer

Major Finding: Endogenous cellular condensates can be functionally perturbed through the recruitment of a micropeptide “killswitch.”Concept: An anti-GFP nanobody recruits the killswitch to GFP-tagged condensates and arrests condensate dynamics.Impact: This technology can be broadly applied to investigate how condensates regulate health and disease, including cancer.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-065
Primary Topic
Photoreceptor and optogenetics research
Type
article
Field-Weighted Citation Impact
0.00
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article

A Micropeptide Killswitch May Shed Light on Condensate Formation in Cancer

Cancer Discovery
Photoreceptor and optogenetics research
article

A Micropeptide Killswitch May Shed Light on Condensate Formation in Cancer

article en

Abstract

Major Finding: Endogenous cellular condensates can be functionally perturbed through the recruitment of a micropeptide “killswitch.”Concept: An anti-GFP nanobody recruits the killswitch to GFP-tagged condensates and arrests condensate dynamics.Impact: This technology can be broadly applied to investigate how condensates regulate health and disease, including cancer.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 78%
Photoreceptor and optogenetics research
DOISourceOpenAlex
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A Micropeptide Killswitch May Shed Light on Condensate Formation in Cancer · Cancer Discovery (2025) | TGRS Research Map | TGRS