Comparison of the Hemodynamic Response of Intravenous and Topical Lidocaine to Endotracheal Intubation

Abstract Aim: To compare the effects of 10% lidocaine spray and intravenous (IV) lidocaine on hemodynamic responses, postoperative throat pain, and coughing following laryngoscopy and endotracheal intubation. Methods: A total of 120 patients, aged 18 to 65 years and scheduled for elective surgery, were randomized into two groups: Group 1 (n=60) received 10% lidocaine spray (three puffs, 30 mg), while Group 2 (n=60) was administered 1.5 mg/kg of IV lidocaine. Intubation was performed by the same individual three minutes after mask ventilation. Systolic, diastolic, and mean arterial blood pressures, along with heart rate, were recorded at baseline and at 2, 4, 6, 8, and 10 minutes after intubation. Immediately upon transfer to the recovery unit, coughing and throat pain were assessed. The data were compared using ANOVA, Scheffe, and repeated measures tests, with the significance level being accepted as p