Release performance and crystallization of racemic and enantiopure praziquantel amorphous solid dispersion in various media
ASDs of ( R , S )-PZQ and ( R )-PZQ were tested in various media. HPMCAS effectively inhibited crystallization, and ( R )-PZQ-HPMCAS showed good release performance. An ASD of ( R )-PZQ may provide a good clinical alternative to the racemic drug.
Authors
- Benedito Roberto de Alvarenga (ORCID: https://orcid.org/0000-0003-2100-0184)
- Lynne S. Taylor (ORCID: https://orcid.org/0000-0002-4568-6021)
Institutions
- Purdue University West Lafayette (US)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5pm00117j
- Citations
- 5
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 3.95
Funders
- Bill and Melinda Gates Foundation