Research on Nano-based Targeted Delivery Systems for Anti-tumor Drugs

Tumor metastasis and recurrence are significant factors leading to patient death, and chemotherapy drugs can cause severe damage to normal cells while killing tumor cells. Therefore, improving the efficacy of chemotherapy drugs and reducing their toxic side effects has become a research hotspot in recent years. Nanotechnology enables efficient targeting of drugs to tumor sites, enhancing the therapeutic effect of anti-tumor drugs. This article reviews the design of nano-based targeted delivery systems for anti-tumor drugs, including nucleic acid aptamers, protein polypeptides, surface modifications, and other nano-carriers and their construction strategies. It introduces various targeting binding systems based on different biomolecules (such as folic acid, hyaluronic acid, sugar chains, etc.) and ligands. This article summarizes the retention behavior of nano-carriers in the body and anticipates future trends in nano-based drug targeting delivery systems.