Innovative Technologies and Quality Evaluation of Oral Sustained-Release and Controlled-Release Preparations

This paper systematically explores the innovative technologies and quality evaluation system of oral sustained-release and controlled-release preparations. By combing the principles and limitations of traditional preparation technologies, it focuses on expounding novel innovative technologies such as ion-exchange resin, microsphere, and 3D printing, along with their application examples, and analyzes the advantages and disadvantages of each technology in drug release control. Meanwhile, it elaborates on the principles and applications of quality evaluation methods, including in vitro release rate test, in vivo bioavailability and bioequivalence evaluation, and in vitro-in vivo correlation evaluation, and illustrates the importance of quality evaluation in the research, development, and quality control of preparations through specific cases. In addition, it discusses the impact of innovative technologies on quality evaluation and proposes strategies for balancing innovation and quality control. The research shows that innovative technologies drive the development of oral sustained-release and controlled-release preparations, and a scientific quality evaluation system is crucial for ensuring the safety and effectiveness of preparations. The coordinated development of these two aspects helps to enhance the clinical application value of preparations.